Dr Fragkou Martha
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Depression

Antidepressant and antipsychotic side-effects and personalised prescribing: a systematic review and digital tool development

Summary Background Side-effects of psychiatric medication impair quality of life and functioning. Furthermore, they contribute to morbidity, mortality, stigma, and poor treatment concordance resulting in relapse of psychiatric illness. Guidelines recommend discussing side-effects with patients when making treatment decisions, but a synthesis of antidepressant and antipsychotic side-effects to guide this process is missing, and considering...
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A New Option for Depressed Patients Who Do Not Respond to Antidepressant Medications

The article by Sachs and colleagues (1) in this issue of the American Journal of Psychiatry describes the main findings of a randomized controlled trial of the second-generation antipsychotic (SGA) cariprazine as an adjunctive treatment for patients with major depressive disorder (MDD). Because not all of the participants had received two or more adequate trials of therapy...
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Alcohol and the Etiology of Depression

In the clinical context, alcohol use is typically a problem to be reduced or eliminated. Patients presenting with depression, anxiety, or other non-substance-related mental disorders often have co-occurring alcohol or other substance use. Community-based surveys show that having an alcohol use disorder at least doubles the odds of depressive, anxiety, and other non-substance-use disorders (1)....
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Insights and Advances Into Treatments for Major Depression

This issue of the Journal is broadly focused on mood disorders, with an emphasis on understanding how treatments for major depressive disorder may work and how the efficacy of current neuromodulation and antidepressant medication treatment strategies can be enhanced. The issue begins with an overview by Drs. Manish Jha and Sanjay Matthew on treatment-resistant depression (1); they...
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Τι είναι κατάθλιψη και τι πρέπει να γνωρίζεις για αυτή

Η Ψυχίατρος Μάρθα Φράγκου, εξηγεί όλα όσα πρέπει να γνωρίζεις. Τι είναι η κατάθλιψη; Η κατάθλιψη είναι μια διαταραχή της διάθεσης που προκαλεί ένα επίμονο αίσθημα θλίψης αλλά και απώλεια ενδιαφέροντος για πράγματα και δραστηριότητες που κάποτε απολαμβάνατε. Μπορεί επίσης να προκαλέσει δυσκολία στη σκέψη, στη μνήμη, στο φαγητό και στον ύπνο. Είναι φυσιολογικό να νιώθετε...
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Depression After Hormonal Contraception Initiation Linked to PPD

Women who have a history of developing depression after initiating hormonal contraception may have a greater risk of developing postpartum depression (PPD), a new study has found. In 2009, Jennifer Payne, M.D., and colleagues wrote an article in the Harvard Review of Psychiatry about the concept of reproductive depression, defined as depressive episodes that are triggered by reproductive hormonal...
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The Intergenerational Impact of Structural Racism and Cumulative Trauma on Depression

Abstract Depression among individuals who have been racially and ethnically minoritized in the United States can be vastly different from that of non-Hispanic White Americans. For example, African American adults who have depression rate their symptoms as more severe, have a longer course of illness, and experience more depression-associated disability. The purpose of this review...
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Increased Stress-Induced Inflammatory Responses in Male Patients With Major Depression and Increased Early Life Stress

Abstract Objective: The authors sought to determine innate immune system activation following psychosocial stress in patients with major depression and increased early life stress. Method: Plasma interleukin (IL)-6, lymphocyte subsets, and DNA binding of nuclear factor (NF)-kB in peripheral blood mononuclear cells were compared in medically healthy male subjects with current major depression and increased early life stress...
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